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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Anesthesiology. 2011 May;114(5):1180–1189. doi: 10.1097/ALN.0b013e31820efb19

Figure 3.

Figure 3

The effect of ondansetron (OND) on morphine tolerance. Morphine dose-response relationships were assessed using the tail flick assay. MPE%: The percent maximal possible effect (%). Panel A presents the morphine dose-response relationships before (baseline) and after 4 days of morphine treatment. Panel B presents the effects of OND (2mg/kg, subcutaneous injection) on morphine analgesic tolerance when administered immediately prior to dose-response testing. Panel C presents the effects of OND administration (1 mg/kg, subcutaneous injection) on morphine analgesic tolerance when administered at the time of each of the bi-daily morphine injections during the 4-day morphine treatment period. Data are presented as the means +/− SEM. Six mice were used in each group.