Table 2.
Effect of OND on Morphine Analgesic Potency
| Treatment | Analgesic ED50 (mg/kg) | 95% Confidence Interval |
|---|---|---|
| Baseline | 4.31 | 3.961 – 5.146 |
| Chronic morphine | 15.08* | 13.56 – 16.78 |
| Acute OND+Chronic Morphine | 5.02 | 4.614 – 5.462 |
| Chronic OND+Chronic Morphine | 4.28 | 3.8000 – 4.817 |
50% morphine analgesic effective dose (ED50)values in animals treated with or without OND were determined by using the sigmoidal fitting-curve method (See statistical analysis).
*
p < 0.05 in comparison of chronic morphine alone with other groups.
OND = Ondansetron