Table I.

Parameter Settings File to Specify the Parameter Initials and Parameter Settings, Covariate Names, Estimation Options, and Estimation Commands

#PNAME	PMEAN	PCOV	PTYPE	PBLOCK	PTRANSF	PLOW	PHIGH	VARINI	VARBURN	VARNIT	VARIT	PBOUNDL	PBOUNDH
CL	5	1	P	1	L			1	30
V1	30	1	P	1	L			1	30
Tout12	10	1	P	2	L			1	30
Imax	0.7	4	P	2	O	0	1	4	30
BASE	15	1	P	2	L			1	30
IC50	10	1	P	2	L			1	30
HILL	1	1	P	2	L			1	30	0.01	40	0.1	20
SDin	1	.	V
SDsl	1	.	V
PDin	1	.	V
PDsl	1	.	V
COVARIATES
RUN_SETTINGS
NFILE	1CMT_PK_with_IDR_1
VERS	1
mdelete <NFILE>_*
DATAFILE	../Data/SA_Example_03_PKPD.csv
COVFILE	../Data/Covariates.csv
BEOFILE	beo.txt
NPOPITER	150
GEFFICIENCY	0.6
PMETHOD	4
NPOP	100
NPOPC	1000
NDELPAR	15
ATOL	5
RTOL	5
gamma_min	0.05
gamma_max	20
beosetup
RUN_COMMANDS
piteraten
?finish.txt
stop

COVARIATES None for this model. External scripts like the commands in the finish.txt file can be included via a “?” sign

PNAME parameter name, PMEAN initial mean, PCOV initial variance, PTYPE parameter type (P = mean with variability, V = residual error parameter), PBLOCK number of block in the variance covariance matrix, PTRANSF parameter transformation type (L = log-normal, O = logistic, N = normal), PLOW lower bound of logistically transformed variable (default = 0), upper bound of logistically transformed variable (default = 1), VARINI initial variance during the variance burn phase, VARBURN number of iterations of the variance burn phase, VARNIT variance after the variance shrink phase, VARIT number of steps in the variance shrink phase, PBOUNDL lower bound for the individual values of a P type parameter, PBOUNDH upper bound for the individual values of a P type parameter, RUN_SETTINGS estimation settings that are called once at the beginning of the estimation (please see S-ADAPT manual for explanation of variables), RUN_COMMANDS sequence of commands to be executed by the S-ADAPT command window