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Global AmB Pharmacokinetic Parameters in Rats Obtained by Non-Compartmental Analysis
| Parameter | Units | Data set | |||
|---|---|---|---|---|---|
| Gershkovich et al., 2009 (3) | Angra et al., 2009 (16) | Fielding et al., 1991 (13) | Combined | ||
| AUC | mg ∙ h/L | 6.29 | 6.75 | 7.00 | 6.63 |
| CL | L/(h ∙ kg) | 0.16 | 0.15 | 0.14 | 0.15 |
| V ss | L/kg | 2.90 | 3.16 | 3.78 | 3.63 |
| T 1/2 | h | 14.5 | 21.9 | 15.2 | 18.0 |
AUC area under the plasma concentration–time curve, CL clearance, V ss steady-state volume of distribution, T 1/2 terminal half-life
