Table III.

Estimated Pharmacokinetic Parameters of AmB in Rats Using a PBPK Model

Parameter	Units	Single dose only (stage 2)		Single and multiple dose (stage 4)
		Estimate	% CV	Estimate	% CV
Kpgi		9.75	17	10.7	18
Kplu		70.1	15	34.3	15
Kpht		2.0	19	2.0	14
Kpli		24.4	13	33.0	11
Clli	L/h	6.00 × 10−2	–a	6.00 × 10−2	–a
f kdu		4.30 × 10−3	14	7.26 × 10−3	19
PSkd	L/h	1.15 × 10−1	28	7.50 × 10−2	31
Kakd	h−1	–b	–	2.58 × 10−1	34
Kdkd	h−1	–b	–	1.29 × 10−3	66
Clkd		1.00 × 10−1	–a	1.00 × 10−1	–a
f spu		2.70 × 10−3	–c	1.71 × 10−3	17
PSsp	L/h	7.47	–c	5.98 × 10−1	26
Kasp	h−1	9.32	–c	9.05 × 10−1	33
Kdsp	h−1	2.37 × 10−2	–c	4.56 × 10−3	20
f rmu		5.00 × 10−2	16	1.60 × 10−2	11
PSrm	L/h	2.12	33	5.47 × 10−1	16
Clrm	L/h	1.10 × 10−1	17	1.58 × 10−1	15

^aFixed to match previously reported values

^bNot estimated

^cFixed to estimate from single-organ model