Fig. 1.

a Mitocryptide-1 is the 23-amino acid C-terminal fragment of cytochrome c oxidase subunit VIII originally identified from porcine heart. The protease that cleaves the precursor protein has not been identified yet. Mitocryptide-1 has been found to activate neutrophils. The fate of N-terminal fragment is not known. b Parstatin is the N-terminal fragment of proteinase activated receptor 1 (PAR1). Parstatin is generated when thrombin cleaves PAR1 for its activation. The cryptide has anti-angiogenic activity