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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Cancer Res. 2011 Mar 8;71(9):3377–3386. doi: 10.1158/0008-5472.CAN-10-4086

Figure 3. Cdk2 absence does not prevent LMW cyclin E expression in the mammary gland.

Figure 3

(A) Immunohistochemistry for human cyclin E protein in mammary glands of MMTV-LMW cyclin E-T1; p53+/-; Cdk2+/+ and MMTV-LMW cyclin E-T1; p53+/-; Cdk2-/-. (B) Cyclin E-associated kinase assays of mammary glands protein lysates from age-matched wild-type (Non-Tg), MMTV-LMW cyclin E; p53+/- mice in Cdk2+/+, Cdk2+/- or Cdk2-/- background was carried out with a cyclin E antibody (HE12) using histone H1 as substrate. The histogram show the relative activities after densitometric scanning (arbitrary units).