Emphysema in the context of spontaneous IFN-γ production is aggravated by the absence of FGF2. (A) Lung volume of each group: (a) WT, (b) FGF2-/-, (c) IFN-γ transgenic, and (d) IFN-γ transgenic crossed with FGF2-/- mice (n=5). (B) Representative H&E-stained lung sections: (a) WT, (b) FGF2-/-, (c) IFN-γ transgenic, and (d) IFN-γ transgenic crossed with FGF2-/- mice. (C) Chord length of each group. * and **P <0.05; * denotes a significant difference compared to WT and FGF2-deficient mice and ** denotes a significant difference compared to
IFN-γ transgenic mice.