Fig. 3.

VAMP8 deficiency leads to histopathological alterations of the thymus. Hematoxylin and eosin staining of sections from the thymus of a 10-day-old wild-type mouse (a) and a healthy adult Vamp8^−/− mouse (30 days old, b) showing two compartments: cortex (Co) and medulla (Me). The thymus of a small and sick Vamp8^−/− mouse (11 days old, c) did not show the characteristic compartmentalization into cortex and medulla. Medullary cells (pink) were scattered throughout the thymic cortex (blue). Micrographs taken at ×100 magnification, bars 100 µm