Fig. 7.

Proportion of proliferating thymocytes was decreased in small and sick Vamp8^−/− mice. a DNA histograms of thymocytes of a small and sick Vamp8^−/− mouse and a Vamp8^+/− control mouse were obtained in a representative flow cytometric analysis. The percentage of proliferating thymocytes in the S and G2 phase is decreased in the Vamp8^−/− mouse. In contrast, the proportion of apoptotic cells in the subG1 area is increased. b Summary of the cell cycle analysis of thymocytes obtained from small and sick Vamp8^−/− mice and heterozygous littermates (bars percentage of thymocytes in cell cycle phases 1+SD; n = 4, age: 9–12 days, *P < 0.05, U test). c Thymi from small and healthy Vamp8^−/− mice (n = 4, age: 9–12 days) show a reduced percentage of proliferating cells compared with heterozygous littermates (*P < 0.05, U test)