a Dot plot of free caspase-3 and -7 activity in CSF from 13 sCJD patients, 9 AD patients, 7 DLB patients, and 8 controls, b caspase activity over clinical status and c remaining lifespan after spinal tap in sCJD-patients, d correlation of caspase-3 and -7 activity with protein tau levels in CSF of sCJD patients