TABLE II.
Pheo Parameters Compared Between VHL Type 2A Families
| Family 1 | Family 2 | P value | |
|---|---|---|---|
| Clinical parameters | |||
| Age first pheo diagnosis (y) (n=30; 33) | 28.8 | 19.7 | 0.02a |
| Diagnosis by symptoms (n=52; 49) | 42 (81%) | 33 (67%) | 0.17 |
| Secretion of Norepi only (n=30; 33) | 19 (63%) | 16 (49%) | 0.31 |
| Secretion of VMA only (n=30; 33) | 4 (13%) | 0 | 0.05a |
| Metachronous pheo (n=65; 65) | 21 (32%) | 13 (20%) | 0.16 |
| Time to new occurrence (y) (n=21; 12) | 7.8 | 12.8 | 0.08 |
| Pathologic parameters | |||
| Size (cm) (n=41; 33) | 3.60 | 3.20 | 0.33 |
| Weight (g) (n=29; 18) | 33.3 | 30.1 | 0.81 |
| R Laterality (n=63; 54) | 20 (32%) | 19 (35%) | 0.84 |
| L Laterality (n=63; 54) | 22 (35%) | 17 (31%) | 1.00 |
| Extra-adrenal (n=63; 54) | 9 (14%) | 15 (28%) | 0.11 |
| Abdominal (n=9; 15) | 7 (78%) | 11 (73%) | 1.00 |
| Organ of zuckerkandl (n=7; 11) | 2 (29%) | 7 (64%) | 0.33 |
| Chest (n=9; 15) | 0 | 3 (20%) | 0.27 |
| Neck (n=9; 15) | 1 (11%) | 0 | 0.37 |
| Synchronous (multifocal at presentation) (n=65; 55) | 26 (40%) | 33 (60%) | 0.04a |
Pheo, pheochromocytoma; Norepi, norepinephrine; VMA, vanillylmandelic acid; y, years.
Not all pheos were informative for each parameter, thus the specific n (Family 1; Family 2) is denoted under each category.
a
Statistical significance.