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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: J Alzheimers Dis. 2010;20(0 2):S591–S607. doi: 10.3233/JAD-2010-100336

Figure 5. A mitocentric view of the multifaceted characteristics of AD.

Figure 5

Changes in glucose metabolism/mitochondria/oxidative stress (GMO) can be feasibly linked to the cognitive changes, plaque, tangles and calcium abnormalities, which define AD. Once initiated by changes in GMO the other deficits can feedback to exaggerate the abnormalities in GMO creating a vicious cycle. This view of AD suggests treatment of the mitochondria/oxidative stress deficit will correct the others whereas treatments targeted at just one facet will fail.