Figure 2.

LASSO method estimates of the risk co-efficients in the Cox proportional hazards model. Co-efficients of high-level CNAs are shown as a function of the shrinkage parameter (straight lines). A shrinkage parameter of 1 denotes the unconstrained model. The first two non-vanishing co-efficients are those of +11q and −18q, followed by +3q and +9q. An evaluation of the generalized cross validation statistic (dashed line) reveals that it is minimal for a shrinkage parameter of 0.05. Only +11q and −18q contribute to the overall risk, making this combination an ideal multivariate marker.