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. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: J Pharmacol Toxicol Methods. 2011 Feb 26;63(3):296–303. doi: 10.1016/j.vascn.2011.02.003

Plasma levels of insulin (A) and c-peptide (B) were reduced by 80–90%, indicating destruction of the vast majority of pancreatic β-cells in STZ-DM monkeys. A trend towards dosedependent reductions in β-cell function as evidenced by c-peptide and insulin is suggested.

Plasma levels of insulin (A) and c-peptide (B) were reduced by 80–90%, indicating destruction of the vast majority of pancreatic β-cells in STZ-DM monkeys. A trend towards dosedependent reductions in β-cell function as evidenced by c-peptide and insulin is suggested.