. Author manuscript; available in PMC: 2012 May 1.

Published in final edited form as: J Pharmacol Toxicol Methods. 2011 Feb 26;63(3):296–303. doi: 10.1016/j.vascn.2011.02.003

Table 2.

Glycemic and IVGTT indices

	Baseline	+3 weeks	+8 weeks	+12 weeks	+16 weeks	Group p-value vs. Control

Post-prandial Glucose (mmol/L)
Control	2.89 ± 0.17	3.27 ± 0.17	3.50 ± 0.28	3.39 ± 0.33	3.11 ± 0.22
STZ-45	2.89 ± 0.17	12.88 ± 2.22	12.27 ± 2.05	11.71 ± 4.27	8.49 ± 3.77	0.01
STZ-55	2.77 ± 0.17	15.43 ± 1.22	12.65 ± 2.05	12.88 ± 2.33	11.99 ± 1.39	0.003
Fructosamine (mEq/L)
Control	163 ± 5	163 ± 8	158 ± 7	165 ± 10	168 ± 14
STZ-45	157 ± 9	343 ± 18 ^*^†	358 ± 23 ^*^†	340 ± 49 ^*^†	397 ± 66 ^*^†	0.001
STZ-55	159 ± 8	391 ± 20 ^*^†	446 ± 19 ^*^†	464 ± 34 ^*^†	462 ± 33 ^*^†	0.0002
IVGTT Glucose AUC
Control	7444 ± 231	6889 ± 383
STZ-45	6675 ± 265	14026 ± 863 ^*^†				0.0001
STZ-55	7734 ± 234	15109 ± 652 ^*^†				0.0001
IVGTT Insulin AUC
Control	3233 ± 298	2921 ± 268
STZ-45	2476 ± 322	221 ± 52 ^*^†				0.0001
STZ-55	2685 ± 416	109 ± 32 ^*^†				0.0001
IVGTT K_g (%/min⁻¹)
Control	3.47 ± 0.28	3.57 ± 0.45
STZ-45	3.40 ± 0.51	1.08 ± 0.12 ^*^†				0.0004
STZ-55	3.17 ± 0.35	1.06 ± 0.10 ^*^†				0.0001
Arginine-Stimulated Insulin AUC
Control		1108 ± 172
STZ-45		111 ± 24 ^†				0.0002
STZ-55		48 ± 15 ^†				0.0001
Arginine Stimulated C-peptide AUC
Control		7547 ± 1248
STZ-45		819 ± 268 ^†				0.0002
STZ-55		586 ± 93 ^†				0.0001

p<0.05 vs. Baseline

^†

p<0.05 vs. CTL