Table I.
Summary data of T cell proliferation experiments
Mitogen | Dosage | Hu > Cpz (No. of Comparisons) | Cpz > Hu (No. of Comparisons) | Dose Response Difference (Approximate)a |
---|---|---|---|---|
L-PHA | 2–10 μg/ml | 11 | 0 | 5× |
ANC 28.1 | 0.125–2.5 μg/ml | 9 | 0 | 5× |
SEB | 2–200 ng/ml | 2 | 0 | 100× |
αCD3 HIT3a | 2.5–250 ng/ml | 8 | 0 | 5× |
αCD3 UCHT1 | 2.5 ng–10 μg/ml | 3 | 0 | 5× |
αCD3 SK7 | 2.5 ng–2.5 μg/ml | 3 | 0 | >10× |
αCD3 SP34 | 2.5 ng–1 μg/ml | 3 | 0 | 5–10× |
MLR | N/A | 6 | 0 | N/A |
Total | 45 | 0 |
This table summarizes all proliferation comparisons between human and chimpanzee T lymphocytes in response to different methods of stimulation. Fig. 1 shows the p values associated with these comparisons.
Refers to the fold difference in amount of stimulating agent needed to get a response from chimpanzee cells similar to that of human cells. At the highest doses studied, the chimp and human lymphocyte responses are mostly similar, with the exception of αCD3 SK7 Ab, where the chimp lymphocytes did not proliferate even at high doses.