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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: J Immunol. 2010 Mar 15;184(8):4185–4195. doi: 10.4049/jimmunol.0903420

Table I.

Summary data of T cell proliferation experiments

Mitogen Dosage Hu > Cpz (No. of Comparisons) Cpz > Hu (No. of Comparisons) Dose Response Difference (Approximate)a
L-PHA 2–10 μg/ml 11 0
ANC 28.1 0.125–2.5 μg/ml 9 0
SEB 2–200 ng/ml 2 0 100×
αCD3 HIT3a 2.5–250 ng/ml 8 0
αCD3 UCHT1 2.5 ng–10 μg/ml 3 0
αCD3 SK7 2.5 ng–2.5 μg/ml 3 0 >10×
αCD3 SP34 2.5 ng–1 μg/ml 3 0 5–10×
MLR N/A 6 0 N/A
Total 45 0

This table summarizes all proliferation comparisons between human and chimpanzee T lymphocytes in response to different methods of stimulation. Fig. 1 shows the p values associated with these comparisons.

a

Refers to the fold difference in amount of stimulating agent needed to get a response from chimpanzee cells similar to that of human cells. At the highest doses studied, the chimp and human lymphocyte responses are mostly similar, with the exception of αCD3 SK7 Ab, where the chimp lymphocytes did not proliferate even at high doses.

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