Table 2.
Patient No. |
Months since MMF start |
MMF dose (mg daily) |
Pred- nisone dose (mg daily) |
DLCO | FVC | FEV1/ FVC (%) |
TLC | SpO2 (on room air) |
Wt (lbs) |
Medication changes after PFT results |
Dyspnea |
---|---|---|---|---|---|---|---|---|---|---|---|
1 | −6 | 0 | 0 | 46 | 77 | 81 | 70 | 84% (walk) 93% (rest) |
217 | Began prednisone 60 mg daily | DOE for 2 months |
1 | −3 | 0 | 40 | 80 | 125 | 79 | 119 | 94% (walk) 97% (rest) |
217 | Began prednisone taper | DOE improved |
1 | −1 | 0 | 30 | 70 | 99 | 82 | 99 | NA | 217 | 1 month later: increased prednisone to 60 mg daily (taper after 2 months), MMF added | DOE increased |
1 | 13 | 3000 | 10.5 | 79 | 106 | 78 | 99 | 96% (rest) | 200 | Continued prednisone taper | No DOE |
1 | 24 | 3000 | 3 | 83 | 104 | 79 | 97 | 96% (rest) | 217 | Finished prednisone taper over next 4 months | No DOE |
1 | 37 | 2000 | 0 | 88 | 121 | 78 | 89 | 95% (rest) | 230 | Continued MMF taper (began taper 4 months ago) | No DOE |
2 | 0 | 0 | 0 | 37 | 76 | 83 | 77 | NA | 200 | Began prednisone 60 mg daily and MMF | Noted DOE in retrospect |
2 | 7 | 3000 | 25 | 76 | 82 | 77 | 83 | 97% (rest) | 216 | Continued prednisone taper (began taper 2 months ago) | No DOE |
2 | 14 | 2000 | 4 | 82 | 87 | 78 | 85 | 98% (rest) | 214 | Continued prednisone taper | No DOE |
3 | −1 | 0 | 7.5 | 44 | 65 | 87 | 73 | NA | 305 | 1 month later: added MMF, increased prednisone to 40 mg daily, stopped methotrexate (12.5 mg weekly) | Noted DOE in retrospect |
3 | 5 | 3000 | 40 | 77 | 69 | 86 | 71 | 100% (rest) | 363 | Started prednisone taper | No change in DOE |
4 | −1 | 0 | 15 | 66 | 73 | 69 | 56 | NA | 210 | 1 month later: MMF added, prednisone taper started | Mild DOE |
4 | 6 | 3000 | 10 | 69 | 64 | 78 | 77 | 99% (rest) | 207 | Continued prednisone taper | DOE improved |
4 | 12 | 3000 | 4 | 82 | 83 | 83 | 86 | 100% (rest) | 211 | Continued prednisone taper | No DOE |
All PFT values (DLCO, FVC, FEV1, TLC) except FEV1/FVC are percent of predicted value. DLCO=diffusing capacity for carbon monoxide, DOE=dyspnea on exertion, FEV1=forced expiratory volume in one second, FVC=forced vital capacity, MMF=mycophenolate mofetil, PFT=pulmonary function test, SpO2=saturation of peripheral oxygen, TLC=total lung capacity