Official websites use .gov
A
.gov website belongs to an official
government organization in the United States.
Secure .gov websites use HTTPS
A lock (
) or https:// means you've safely
connected to the .gov website. Share sensitive
information only on official, secure websites.
Clinical diagnosis, sample size and age distribution of participants with gene mutations affecting the Ras/MAPK signaling pathway
| Clinical diagnosis | Gene | n | Age range | Mean age |
|---|---|---|---|---|
| Noonan syndrome | ||||
| PTPN11 | 50 | 1.0–24.5 | 7.6 | |
| SOS1 | 11 | 3.2–16.9 | 10.3 | |
| RAF1 | 3 | 1.7–9.8 | 4.8 | |
| KRAS | 2 | 1.4–3.8 | 2.6 | |
| BRAF | 1 | 14.3 | 14.3 | |
| CFC syndrome | ||||
| BRAF | 19 | 1.1–21.6 | 9.1 | |
| MEK1 | 1 | 9.8 | 9.8 | |
| MEK2 | 2 | 10.4–14.3 | 12.3 | |
