Table 4.

Multivariable modeling of influence of lesion burden on cognitive function and disability in 147 CADASIL patients.

Step	Variables	Beta	p-Value	Total explained variance	Standardized beta
Global cognitive function (MDRS)
1	BPF	1.37	<0.0001	0.35	0.40
2	LL	−53.8	0.0057	0.42	−0.21
3	Mean-ADC	−2.73	0.0117	0.53	−0.21
MDRS-initiation
1	BPF	0.50	<0.0001	0.42	0.39
2	LL	−24.8	0.0002	0.50	−0.26
3	Mean-ADC	−0.86	0.0228	0.53	−0.17
4	Age	−0.10	0.0447	0.55	−0.15
Disability (mRS)
1	BPF	−0.12	<0.0001	0.38	−0.46
2	LL	6.19	<0.0001	0.51	0.33
3	CM	0.05	0.0017	0.55	0.21

MDRS, Mattis dementia rating scale; CM, cerebral microhemorrhage; LL, lacunar lesion volume; WMH, white matter hyperintensities; mean-ADC, mean adjusted diffusion coefficient; BPF, brain parenchymal fraction. Variables were added to the model in a stepwise fashion. Total explained variance describes total variance as variables are progressively added to the model.