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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: Biochem Pharmacol. 2001 Sep 1;62(5):569–580. doi: 10.1016/s0006-2952(01)00695-5

Fig. 2.

Fig. 2

Effects of changes in the pH and/or temperature of the growth medium on the leishmanicidal activity of ASM against promastigotes. Growing cultures of the L. amazonensis promastigotes (~1 × 107 cells/ mL) were incubated with 20 µM SSM or ASM for 20 hr at 25° or at 35°, pH 7.5 or 4.5, with or without PLL (10 µg/mL). Results are means ± SEM (N = 6). Similar results were obtained with L. major and L. donovani promastigotes. PLL alone at 10 µg/mL had a marginal effect on growth at pH 7.5. The differences of antileishmanial activities between ASM and SSM were statistically significant (P < 0.05 at pH 7.5 and P < 0.01 at pH 4.5).