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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Pediatr Res. 2011 Apr;69(4):285–292. doi: 10.1203/PDR.0b013e31820bd165

Table 2.

Selected Morphine-responsive genes*, unaffected by stress (92 genes)

Gene Symbol Gene Description MSM-MSS (log2FC)** MSM-MSS p-value† SSM-SSS (log2FC)** SSM-SSS p-value†
Accn4 amiloride-sensitive cation channel 4 0.400 0.114 0.605 0.024
Aqpl aquaporin 1 1.187 0.030 0.260 0.600
Avprla arginine vasopressin receptor 1A -0.704 0.024 -0.160 0.570
Bex4 brain expressed gene 4 0.015 0.901 0.389 0.006
Carhspl calcium regulated heat stable protein 1 0.221 0.300 0.477 0.037
Cdh22 cadherin 22 0.026 0.861 0.405 0.016
Cldn2 claudin 2 0.744 0.029 0.245 0.430
Ctnnall catenin (cadherin associated protein), alpha-like 1 0.415 0.021 0.137 0.396
Cux2 cut-like homeobox 2 0.653 0.013 0.007 0.977
Dlx5 distal-less homeobox 5 0.088 0.752 0.614 0.044
Dock10 dedicator of cytokinesis 10 0.122 0.445 0.410 0.027
Gabra4 gamma-aminobutyric acid (GABA-A) receptor, subunit alpha 4 0.101 0.385 0.392 0.004
Gad2 glutamic acid decarboxylase 2 0.231 0.424 0.609 0.0495
Gal galanin 0.408 0.033 0.074 0.669
Gh growth hormone -0.189 0.514 -0.854 0.010
Glra2 glycine receptor, alpha 2 subunit 0.171 0.414 0.441 0.049
Mpeg1 macrophage expressed gene 1 0.017 0.870 0.384 0.003
Npy neuropeptide Y 0.305 0.052 0.539 0.002
Reln reelin -0.097 0.532 -0.491 0.007
Rgs6 regulator of G-protein signaling 6 0.439 0.010 0.066 0.657
Tac1 tachykinin 1 0.083 0.860 1.374 0.012
Trh thyrotropin releasing hormone 0.700 0.029 0.275 0.350

Columns 1 and 2 list Gene symbols and gene descriptions. Columns 3 [MSM-MSS (log2FC)] and 5 [SSM-SSS (log2FC)] provide the log2 transformed change in expression caused by mild-stress-morphine (MSM) treatment relative to the mild-stress-saline (MSS) treatment, and the severe-stress-morphine (SSM) treatment relative to severe-stress-saline (SSS) treatment respectively. Columns 4 (MSM-MSS p-value) and 6 (SSM-SSS p-value) list the p-values associated with the aforementioned contrasts.

*

morphine responsive genes are defined as changing >1.3-fold (up or down) with p<0.05 in either the MSM-MSS or the SSM-SSS contrast

**

fold change is provided as log2, positive numbers indicate gene was expressed at higher level in MSM vs. MSS or SSM vs. SSS respectively, whereas negative numbers indicate the opposite, bold print indicates a > 1.3-fold absolute change

†

bold print indicates p<0.05.