Table 3.
Selected genes responding only when Stress and Morphine are present together (104 genes total).
| Gene Symbol | Gene Description | Stress × Morphine Interaction (log2FC)* | Stress × Morphine Interaction p-Value |
|---|---|---|---|
| C1ql3 | C1q-like 3 | 0.497 | 0.038 |
| Calbl | calbindin-28K dehydrogenase/reductase (SDR family) | 0.557 | 0.011 |
| Dhrs7b | member 7B | 0.396 | 0.011 |
| Dnahc3 | dynein, axonemal, heavy chain 3 | -0.440 | 0.013 |
| Dynclhl | dynein cytoplasmic 1 heavy chain 1 | -0.385 | 0.005 |
| Ephx2 | epoxide hydrolase 2, cytoplasmic | 0.384 | 0.004 |
| Fbnl | fibrillin 1 | -0.412 | 0.013 |
| Hs6st2 | heparan sulfate 6-O-sulfotransferase 2 | 0.4345 | 0.012 |
| Htr3a | 5-hydroxytryptamine (serotonin) receptor 3A low density lipoprotein receptor-related | 0.591 | 0.018 |
| Lrp1 | protein 1 malic enzyme 3, NADP(+)-dependent, | -0.445 | 0.012 |
| Me3 | mitochondrial | 0.401 | 0.035 |
| Myo19 | myosin XIX | -0.392 | 0.001 |
| Nav1 | neuron navigator 1 | -0.385 | 0.015 |
| Pknox1 | Pbx/knotted 1 homeobox | 0.434 | 0.001 |
| Rab11b | RAB11B, member RAS oncogene family ribonucleotide reductase M2 B (TP53 inducible) | 0.392 | 0.019 |
| Rrm2b | 0.384 | 0.010 | |
| Sst | somatostatin | 0.497 | 0.006 |
| Syt5 | synaptotagmin V | 0.379 | 0.014 |
| Trhr | thyrotropin releasing hormone receptor | 0.487 | 0.046 |
| Ttll11 | tubulin tyrosine ligase-like family, member 11 thioredoxin domain containing 4 | 0.441 | 0.008 |
| Txndc4 | (endoplasmic reticulum) | 0.381 | 0.019 |
| Zfp239 | zinc finger protein 239 | 0.380 | 0.009 |
*
fold change is provided as log2, positive numbers indicate that the Stress X Morphine interaction effect increased gene expression, whereas a negative number indicates the opposite.