Table 3.
Results of multivariate analysis for markers of renal flare
| p-values |
||||
|---|---|---|---|---|
|
Main effector analysis |
Interaction analysis |
|||
| Predictors for identification of markers | Initial univariate analysis | Final multivariate analysis | Final multivariate analysis | Pro-flare effect of individual RF marker |
| C3 | <0.001 | <0.001 | <0.001 | lower C3 levels |
| C4 | <0.001 | 0.787 | ||
| ESR | <0.001 | 0.003 | 0.002 | higher ESR levels |
| CRP | 0.561 | 0.765 | ||
| Age | 0.022 | 0.015 | 0.028 | younger age |
| C3 carrier | 0.637 | 0.139 | ||
| FH genotype | 0.198 | 0.193 | 0.030 * | |
| CRP4 carrier | 0.015 | 0.017 | 0.023 | 1846GG (WT) |
| C3 × C3 carrier | 0.062 | |||
| C3 × FH genotype | 0.016 | |||
| C3 × CRP4 carrier | 0.067 | |||
| CRP × C3 carrier | 0.307 | |||
| CRP × FH genotype | 0.421 | |||
| CRP × CRP4 carrier | 0.100 | |||
*
FH genotype is significant only through its interactions with C3.
RF, renal flare; ESR, erythrocyte sedimentation rate; CRP, C-reactive protein; FH, factor H; WT, wildtype.