Table 3.

Incremental value of high-density lipoprotein cholesterol and its apolipoproteins over lipoprotein and metabolic parameters in coronary calcium prediction

Added to	HDL Cholesterol		ApoA-I		ApoA-II
	No T2DM (n = 803)	T2DM (n = 611)	No T2DM (n = 803)	T2DM (n = 611)	No T2DM (n = 803)	T2DM (n = 611)
HDL cholesterol	—	—	0.01	0.74	0.03	0.49
ApoA-I	4.09*	8.59†	—	—	0.11	0.00
ApoA-II	8.24†	11.20‡	4.38*	2.86	—	—
Total cholesterol	17.10‡	13.49‡	13.93‡	5.12*	8.21†	2.15
Low-density lipoprotein cholesterol	9.35†	12.13‡	6.78*	4.21*	4.07*	1.54
ApoB	4.15*	9.43†	6.37*	3.97*	4.38*	1.91
Triglycerides	3.06	4.46*	4.56*	2.37	3.85*	1.88
Waist circumference	2.39	8.10†	2.98	3.12	1.60	0.89
HOMA-IR	2.64	4.47*	2.12	1.38	2.26	0.30

Likelihood ratio testing was applied in nested tobit models primarily to assess the incremental value of HDL cholesterol over its apolipoproteins, and vice versa, in predicting CAC scores. All models presented in the table included age, gender, and medications. Chi-square values are presented.

^*p <0.05

^†p <0.01

^‡p <0.001.