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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: Curr Drug Abuse Rev. 2009 Sep;2(3):243–255. doi: 10.2174/1874473710902030243

Fig. (1).

Fig. (1)

Effects of the nAChR agonist nicotine and the nAChR antagonist mecamylamine on nicotine self-administration and nicotine discrimination. Panel A demonstrates that nicotine (0.03–0.3 mg/kg, SC; 15-min pretreatment interval [PTI]) and mecamylamine (0.3–3.0 mg/kg, SC; 15-min PTI) both decrease the (mean ± SEM) number of nicotine (0.03 mg/kg/infusion) infusions earned in rats (n = 6) trained to self-administer nicotine under a fixed ratio 5 (FR5) reinforcement schedule during daily 60-min sessions. Panel B demonstrates that nicotine (0.03–0.3 mg/kg, SC; 5-min PTI), but not mecamylamine (0.3–3.0 mg/kg, SC; 15-min PTI), produces a dose-dependent increase in the percentage of nicotine-appropriate responses in rats (n = 6) trained to discriminate nicotine (0.3 mg/kg, SC) from saline under a FR10 reinforcement schedule during daily 15-min sessions. Panel C illustrates the effects of nicotine and mecamylamine on response rates (responses/sec) corresponding to the data presented in panel B.