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. Author manuscript; available in PMC: 2012 Apr 20.
Published in final edited form as: Bioconjug Chem. 2011 Mar 9;22(4):808–818. doi: 10.1021/bc100478k

Fig. 1. Schematic of SLN-BAT.

Fig. 1

The lipid-PEG-BAT (left) molecule is incorporated into the SLN such that the stearic acid lipid tail is embedded in the stearic acid lipid core, while the PEG is associated with the lecithin monolayer, and the BAT chelator remains accessible from outside the SLN (right). We anticipate that van der Walls forces would cause the lipid portion of the lipid-PEG-BAT molecule to associate with the lipid core of the SLN and there be incorporated inside. We also anticipate that van der Walls forces would cause the hydrophilic PEG portion of the lipid-PEG-BAT to be associated with the hydrophilic headgroups of the lecithin molecule, leaving the BAT accessible on the surface of the SLN. By testing the ability for the SLNs to radiolabel 64Cu, we validate the incorporation of lipid-PEG-BAT into the SLN and the accessibility of the BAT groups on the surface.