Table 1.

Anatomical coordinates for regions of significant difference between the sleep control and sleep deprivation groups in response to the emotional stimulus gradient

Region	Cluster size (voxels)	x	y	z	Peak Z score	SVC p
Sleep deprivation > sleep control
Amygdalaa,b,c
L	47	−24	−9	−21	3.65	0.012
R	12	30	3	−18	3.39	0.032
Insular cortex—La,b,c,d	20	−44	4	3	3.60	0.027
Putamen—Lb,d,e	9	−30	5	−2	3.62	0.026
Substantia nigra/ventral tegmental areab,d,f,g,h	9	0	−21	−18	3.51	0.007
Fusiform gyrus—L*	46	−24	−54	−12	4.44
Sleep control > sleep deprivation
Posterior hippocampal cortex—R*	7	30	−28	−9	3.51
Precuneus—L*	8	0	−39	57	3.16
Middle occipital gyrus—L*	5	−27	−87	−3	3.12

The x–y–z coordinates are given in peak Montreal Neurological Institute (MNI) space coordinates. L and R denote left and right.

* denotes non-a priori regions that were significant at p < 0.001 uncorrected threshold, but did not survive whole-brain FDR correction at p < 0.05. All other areas were of a priori interest, defined by letter (a–g), and all survived SVC correction for multiple comparisons (p < 0.05, 10 mm³ sphere; with the exception of the small substantia nigra/VTA nuclei, which used a 5 mm³ sphere).

^aKarama et al. (2002).

^bGottfried et al. (2003).

^cSabatinelli et al. (2007).

^dKnutson et al. (2005).

^eValentin and O'Doherty (2009).

^fAdcock et al. (2006).

^gKuhl et al. (2010).

^hD'Ardenne et al. (2008).