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. Author manuscript; available in PMC: 2011 May 3.
Published in final edited form as: Synth Commun. 2011 Jan 1;41(3):319–330. doi: 10.1080/00397910903537364

Scheme 1.

Scheme 1

Reagents and conditions: (i) Br2; (ii) EtOH, reflux; (iii) (Bu3Sn)2, Pd(PPh3)4; (iv) 2-tributyltin thiophene, Pd(PPh3)4; (v) DMF-POCl3; (vi) 5-formylthiophen-2-ylboronic acid; (vii) 3,4-diaminobenzonitrile, sodium bisulfite, DMF, reflux.