Figure 2.

Depurinating estrogen-DNA adducts in the urine of healthy control women, women at high risk for breast cancer, and women with breast cancer. The ordinate of this bar graph corresponds to the ratio of depurinating DNA adducts divided by their respective estrogen metabolites, and thiol and methyl conjugates:

$$\left[\frac{{4-\text{OHE}}_1\hspace{0.17em}({\text{E}}_2)-1-\text{N}3\text{Ade}+4{-\text{OHE}}_1\hspace{0.17em}({\text{E}}_2)-1-\text{N}7\text{Gua}}{4-\text{catechol}\hspace{0.17em}\text{estrogens}+4-\text{catechol}\hspace{0.17em}\text{estrogen}\hspace{0.17em}\text{conjugates}}+\frac{{2-\text{OHE}}_1\hspace{0.17em}({\text{E}}_2)-6-\text{N}3\text{Ade}}{2-\text{catechol}\hspace{0.17em}\text{estrogens}+2-\text{catechol}\hspace{0.17em}\text{estrogen}\hspace{0.17em}\text{conjugates}}\right]\times 1000,$$

i.e.

$$\left[\frac{\text{No}.37+38+35+36}{\text{No}.8+9+14+15+29\hspace{0.17em}\text{through}\hspace{0.17em}34}+\frac{\text{No}.39+40}{\text{No}.6+7+12+13+16\hspace{0.17em}\text{through}\hspace{0.17em}28}\right]\times 1000\hspace{0.17em}(\text{see}\hspace{0.17em}\text{Table}\hspace{0.17em}1\hspace{0.17em}\text{for}\hspace{0.17em}\text{the}\hspace{0.17em}\text{numbers}).$$