Table 1.
List of activated PSC proteins selected for further validation. The activated PSC secretome was sorted by total number of sequenced peptides per protein to estimate relative abundance. The most abundant proteins were screened via literature search to identify those most likely to play a role in cancer progression. These proteins were then chosen for further validation by western blot and IHC analysis.
GI accession # | Abbreviation | Protein Name |
---|---|---|
gi|5453886 | SERPINI2 | serpin peptidase inhibitor, clade I (pancpin), member 2 |
gi|4505863 | PLAU | urokinase plasminogen activator preprotein |
gi|10835159 | SERPINE1 | plasminogen activator inhibitor - 1 |
gi|11342666 | MMP2 | matrix metallopeptidase 2 |
gi|4507467 | TGFBI | transforming growth factor, beta-induced, 68kDa |
gi|5031863 | LGALS3BP | galectin-3-binding protein |
gi|33286418 | PKM2 | pyruvate kinase, muscle isoform 1 |
gi|66392203 | NME1 | nucleotide diphosphate kinase 1 |
gi|161702986 | EZR | ezrin |
gi|50845386 | ANXA2 | annexin A2 |
gi|21361091 | UCHL1 | ubiquitin carboxyl-terminal esterase L1 |