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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Mar 2;252(3):259–267. doi: 10.1016/j.taap.2011.02.017

Figure 3.

Figure 3

Nonylphenol is a weak activator of human PXR in vivo. Western blots of hepatic microsomes were performed for Cyp2b, Cyp3a, and β-actin from hepatic microsomes of male and female humanized mice treated with 0, 50, or 75 mg/kg/day NP. Actin was used as a housekeeping gene. A) Female untreated and NP-treated hPXR mice. B) Male untreated and NP-treated hPXR mice. Blots were quantified densitometrically and the relative mean differential expression as compared to the controls is reported above the blots. An asterisk indicates a statistically significant difference compared to the untreated group using Student's t-test (p < 0.05).