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Liver histopathology in untreated and 50 mg/kg/day NP treated mice. Mouse liver fragments were stained using hematoxylin and eosin and examined as described in the Materials and Methods. A) Untreated wild-type mouse liver. B) NP treated wild-type mouse liver. C) Untreated PXR-null mouse liver. D) NP treated PXR-null mouse liver.
