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. Author manuscript; available in PMC: 2012 May 1.
Published in final edited form as: Toxicol Appl Pharmacol. 2011 Mar 2;252(3):259–267. doi: 10.1016/j.taap.2011.02.017

Table 4.

Nonylphenol serum concentrations, as measured by GC-MS in mice treated with 0, 50, or 75 mg/kg/day NP.

A. Female
NP WT# PXR-null# hPXR#
0 0.0285 + 0.0179 0.0221 ± 0.0122b 0.1182 ± 0.0250
50 0.0926 ± 0.0322 0.1493 ± 0.0223b 0.0950 ± 0.0133
75 0.0791 ± 0.0100 0.0574 ± 0.0279 0.0796 ± 0.0060
B. Male
NP WT PXR-null hPXR
0 0.0103 ± 0.0042 0.0335 ± 0.0255b 0.0343 ± 0.0038
50 0.0783 ± 0.0468 0.1432 ± 0.0118b 0.1250 ± 0.0343
75 0.0024 ± 0.0011 0.0292 ± 0.0144 0.0585 ± 0.0121d
C. Male and Female
NP WT PXR-null hPXR
0 0.0194 ± 0.0092a 0.0283 ± 0.0099c 0.0902 ± 0.0237
50 0.0856 ± 0.0264a 0.1459 ± 0.0076c 0.1086 ± 0.0169
75 0.0364 ± 0.0141 0.0433 ± 0.0108 0.0690 ± 0.0077
#

Data is expressed as mean (μg/ml) ± SEM (n = 4-6 or n = 8-12 for combined male and female data). Detection limit was of 0.01μg/ml. Values calculated below detection limit but higher than 0 were assigned a value of ½ detection limit.

a

Indicates significant difference between untreated and NP-treated mice (p-value < 0.05)

b

Indicates significant difference between untreated and NP-treated mice (p-value < 0.01)

c

Indicates significant difference between untreated and NP-treated mice (p-value < 0.0001)

d

Indicates significant difference between WT and hPXR mice (p-value < 0.05)

Statistical significance determined by ANOVA followed by Dunnett's multiple comparison test.