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Manipulating immune tolerance with chemotherapy
| Immunologic Effect | Chemotherapy Drugs |
|---|---|
| Abrogate suppressive influence of Treg | Cyclophosphamide, Fludarabine |
| Relieve inhibition mediated by myeloid suppressor cells | Gemcitabine |
| Enhance dendritic cell migration/maturation | Paclitaxel, Docetaxel |
| Reversal of immunologic skew | Cyclophosphamide, Paclitaxel, Bleomycin, Melphalan |
| Promote evolution of the memory response | Cyclophosphamide |
| Promote homeostatic T cell proliferation | High dose chemotherapy |
