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Aging and infection reduce activation of TrkB and downstream activity in major TrkB-signaling pathways. A–D, Levels of phosphorylated TrkB (A), PLC-γ1 (B), and ERK (C) were significantly lower in synaptoneurosomes prepared from aged animals 5 d following infection; levels of phosho-Akt (D) were not. Quantification was as described in the Fig. 1 legend.
