Universal tumor antigens |
Telomerase, hTERT, survivin, mdm-2, CYP-1B1 |
All |
Cancer testis antigens |
MAGE, BAGE, RAGE, GAGE, NY-ESO-1 |
Breast, prostate, testicular, bladder, melanoma, gastric, esophageal, hepatocellular, renal, lung, head and neck |
Tissue-specific differentiation products |
PSA |
Prostate |
Tyrosinase, Mart-1/Melan-A, gp100, trp-1, trp-2 |
Melanoma |
Mutated gene products |
CDK-4-R24C |
Renal |
β-catenin |
Colon |
p53 |
Colon, breast, lung |
k-ras |
Colon, pancreas, lung, esophageal |
bcr-abl |
Leukemia |
MUM-1 |
Leukemia |
Overexpressed self-antigens |
HER-2/neu |
Breast |
Proteinase-3 |
Leukemia |
Mucin-1 |
Multiple myeloma, pancreas, gastric, breast |
WT-1 |
Leukemia |
MART-1/melan-A |
Melanoma |
Mesothelin |
Pancreas, ovarian, peritoneal, mesothelioma |
Idiotypes |
Ig, TCR |
Lymphoma |