The course of an acute rejection is shown at right in record of a 23-year-old woman who underwent transplantation for hepatoma. Although the rejection crisis was overcome promptly, she died of pseudomonas pneumonia after 35 days. Even before the onset of jaundice her course was markedly febrile and she had severe bleeding problems: note marked depression of prothrombin time and fibrinogen concentration on days 10 through 13.