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Pharmacokinetic variables of EKB-569 and N-desmethyl EKB-569 on day 8
| Compound | Cmax (ng/mL) | Tmax (h) | T1/2 (h) | AUC (ng·h/mL) | Cl/F (L/h) | Vss/F (L) |
|---|---|---|---|---|---|---|
| EKB569 | 42.3 ± 15.1 | 4 (2–8) | 16.6 ± 3.7 | 633 ± 234 | 57 ± 24 | 1,295 ± 445 |
| N-Demethy EKB-569 | 4.2 ± 3.2 | 3.5 (2–6) | 24.1 ± 9.2 | 64.4 ± 43.3 |
NOTE: Values are mean ± SD except for Tmax, which are mean and range.
Abbreviations: Tmax, time to Cmax; Cl/F, oral clearance; Vss/F, volume of distribution at steady-state after p.o. administration.
