Table 5.

Pharmacokinetic variables of capecitabine and its metabolites on day 1 and day 8

Compound	Concurrent EKB-569 administration	Tmax (h)	Cmax (ng/mL)	AUC[0-t] (h·ng/mL)	AUC[0-∞] (h·ng/mL)	T1/2 (h)
Capecitabine	Alone	1.00 (0.50–3.00)	3,808 ± 1,896	5,247 ± 971	5,296 ± 1,015	0.52 ± 0.17
	Combination	1.00 (0.50–3.00)	5,771 ± 6,838	6,868 ± 3,559	8,119 ± 3,595	0.53 ± 0.22
	P	0.89	0.81	0.15	0.072	0.51
5′-DFUR	Alone	2.00 (0.50–4.00)	5,787 ± 3,996	10,027 ± 4,052	10,228 ± 4,263 (12)	0.72 ± 0.14
	Combination	2.50 (0.50–4.00)	6,618 ± 5,043	12,846 ± 5,077	13,356 ± 5,336	0.87 ± 0.63
	P	0.12	0.92	0.036	0.028	0.33
5-FU	Alone	2.00 (0.50–4.00)	102 ± 96	165 ± 63	176 ± 62	0.73 ± 0.17
	Combination	2.50 (0.50–4.00)	191 ± 204	311 ± 155	321 ± 151	1.00 ± 0.75
	P	0.17	0.10	0.0012	0.0037	0.24

NOTE: Values are means ± SD (n) except T_max values are median (range; n). P values are for a paired two-tailed Student’s t test.