Table 3.
Proportions of pfcrt 76T and 76K and pfmdr1 86Y and 86N Alleles on Day 0 and by Day 42a
| Chloroquine |
Artemether-Lumefantrine |
|||||||||
| Allele Proportions on Day 0 and the Day of PCR-adjusted Treatment Failure (%) |
||||||||||
| Pfcrt 76T | Pfcrt 76K | Pfmdr1 86Y | Pfmdr1 86N | No. of Children in whom pfcrt and pfmdr1 Genotypes Were Identified | Pfcrt 76T | Pfcrt 76K | Pfmdr1 86Y | Pfmdr1 86N | No. of Children in whom pfcrt and pfmdr1 Genotypes Were Identified | |
| Day 0b | 45 (31) | 105 (72) | 58 (40) | 99 (68) | 146 | 38 (24) | 129 (82) | 50 (32) | 121 (78) | 157c |
| Treatment Failure | 8 (100) | 0 (0) | 5 (63) | 3 (37) | 8 | 0 (0) | 3 (100) | 0 (0) | 3 (100) | 3 |
| P value | <.001 | <. 001 | .18 | .09 | .44 | .56 | .32 | .47 | ||
| Allele Proportions on Day 0 and the Day of Reinfection | ||||||||||
| All Day 0 | 109 (29) | 283 (76) | 135 (37) | 268 (73) | 371d | 109 (29) | 283 (76) | 135 (37) | 268 (73) | 371d |
| Reinfections | 4 (40) | 6 (60) | 4 (40) | 6 (60) | 10 | 3 (30) | 7 (70) | 1 (11) | 8 (89) | 10e |
| P value | .34 | .20 | .53 | .29 | .60 | .44 | .11 | .25 | ||
NOTE. PCR, polymerase chain reaction.
a
Proportions were calculated by dividing the number of samples with a specific allele by the number of samples in which PCR was successful. Mixed infections thus contributed to the proportion of both alleles
b
Alleles in children with PCR-corrected adequate clinical and parasitological responsea by day 42.
c
The pfmdr1 haplotype was identified in 156 children.
d
The pfcrt haplotype was not identified in 7 children, and the pfmdr1 haplotype was not identified in 9 children.
e
The pfmdr1 genotype was identified 9 children.