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. 2011 Jan 1;203(1):109–116. doi: 10.1093/infdis/jiq001

Table 4.

Median Temperatures and Clinical Condition from Day 0 through Day 3

Day 0
Day 1
Day 2 Day 3
Variable 1st Dose Second Dose Third Dose Fourth Dose Fifth Dose Sixth Dose After Treatment
No. of Plasmodium falciparum isolates/μL, median
CQ 26,667 9080 280 0
AL 22,346 680 0 0
P value .40 <. 001 <. 001
Temperature, median (95% CI), °C
CQ 38.0 36.7 36.4 36.3 36.3 36.2 36.2
AL 38.1 36.7 36.5 36.3 36.2 36.2 36.1
P value .54 .93 .46 >.99 .09 >.99 .08
Proportion of Children with Poor or Moderate Clinical Condition
CQ 0.93 0.83 0.60 0.54 0.46 0.38 0.11
AL 0.93 0.83 0.65 0.53 0.40 0.29 0.15
P value .74 .99 .38 .94 .24 .10 .33

NOTE. AL, artemether-lumefantrine; CI, confidence interval; CQ, chloroquine.