Table 4.
Day 0 |
Day 1 |
Day 2 | Day 3 |
||||
Variable | 1st Dose | Second Dose | Third Dose | Fourth Dose | Fifth Dose | Sixth Dose | After Treatment |
No. of Plasmodium falciparum isolates/μL, median | |||||||
CQ | 26,667 | 9080 | 280 | 0 | |||
AL | 22,346 | 680 | 0 | 0 | |||
P value | .40 | <. 001 | <. 001 | – | |||
Temperature, median (95% CI), °C | |||||||
CQ | 38.0 | 36.7 | 36.4 | 36.3 | 36.3 | 36.2 | 36.2 |
AL | 38.1 | 36.7 | 36.5 | 36.3 | 36.2 | 36.2 | 36.1 |
P value | .54 | .93 | .46 | >.99 | .09 | >.99 | .08 |
Proportion of Children with Poor or Moderate Clinical Condition | |||||||
CQ | 0.93 | 0.83 | 0.60 | 0.54 | 0.46 | 0.38 | 0.11 |
AL | 0.93 | 0.83 | 0.65 | 0.53 | 0.40 | 0.29 | 0.15 |
P value | .74 | .99 | .38 | .94 | .24 | .10 | .33 |
NOTE. AL, artemether-lumefantrine; CI, confidence interval; CQ, chloroquine.