Table 3.
Summary of anogenital HPV serology and DNA status (A) and multiple HPV exposure (B) at enrollment among men who have sex with men
| A. HPV DNA Positivity and Seropositivity | ||||||
| HPV Type | HPV DNA Positivity n (%) |
Serum n (%) | ||||
| External Genital Anatomic Sites |
Anal Canal | External Genital and/or Anal Sites | ||||
| Penile | Scrotal | Perineal/Perianal | ||||
| Any tested type* | — | — | — | — | 284 (48.1) | 135 (22.8) |
| HPV 6/11/16/18 | 61 (11.2) | 49 (9.2) | 102 (19.2) | 148 (25.2) | 180 (30.5) | 135 (22.8) |
| HPV 16/18 | 35 (6.4) | 24 (4.5) | 59 (11.1) | 93 (15.8) | 112 (19.0) | 62 (10.5) |
| HPV 16 | 19 (3.5) | 13 (2.4) | 36 (6.8) | 70 (11.9) | 81 (13.7) | 42 (7.1) |
| HPV 18 | 17 (3.1) | 11 (2.1) | 26 (4.9) | 38 (6.5) | 48 (8.1) | 27 (4.6) |
| HPV 6/11 | 33 (6.0) | 28 (5.3) | 59 (11.1) | 87 (14.8) | 107 (18.1) | 108 (18.2) |
| HPV 6 | 24 (4.4) | 20 (3.8) | 43 (8.1) | 65 (11.1) | 79 (13.4) | 83 (14.0) |
| HPV 11 | 11 (2.0) | 8 (1.5) | 20 (3.8) | 31 (5.3) | 40 (6.8) | 38 (6.4) |
| HPV 31 | 9 (1.7) | 7 (1.3) | 18 (3.4) | 33 (5.6) | 41 (6.9) | — |
| HPV 33 | 3 (0.6) | 2 (0.4) | 10 (1.9) | 16 (2.7) | 18 (3.1) | — |
| HPV 35 | 4 (0.7) | 3 (0.6) | 11 (2.1) | 24 (4.1) | 25 (4.2) | — |
| HPV 39 | 7 (1.3) | 7 (1.3) | 19 (3.6) | 36 (6.1) | 43 (7.3) | — |
| HPV 45 | 10 (1.8) | 11 (2.1) | 25 (4.7) | 39 (6.6) | 46 (7.8) | — |
| HPV 51 | 11 (2.0) | 13 (2.4) | 34 (6.4) | 46 (7.8) | 54 (9.1) | — |
| HPV 52 | 5 (0.9) | 3 (0.6) | 15 (2.8) | 29 (4.9) | 35 (5.9) | — |
| HPV 56 | 17 (3.1) | 12 (2.3) | 38 (7.1) | 60 (10.2) | 73 (12.4) | — |
| HPV 58 | 5 (0.9) | 3 (0.6) | 14 (2.6) | 24 (4.1) | 25 (4.2) | — |
| HPV 59 | 6 (1.1) | 4 (0.8) | 16 (3.0) | 32 (5.5) | 37 (6.3) | — |
| * HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59 for DNA detection; HPV 6, 11, 16, and 18 for serology. | ||||||
| B. Multiple HPV Positivity (Both DNA Positivity and Seropositivity) | ||||||
| Number of Types Detected | ||||||
| HPV DNA Positivity n (%) |
Serumn (%) | |||||
| External Genital Anatomic Sites |
Anal Canal | External Genital and/or Anal Sites | ||||
| Penile | Scrotal | Perineal/Perianal | ||||
| Any tested types* | ||||||
| 0 | 445 (81.4) | 441 (82.9) | 357 (67.0) | 338 (57.6) | 307 (52.0) | — |
| 1 | 71 (13.0) | 71 (13.4) | 94 (17.6) | 121 (20.6) | 128 (21.7) | — |
| 2 | 22 (4.0) | 17 (3.2) | 42 (7.9) | 47 (8.0) | 61 (10.3) | — |
| 3 | 3 (0.6) | 1 (0.2) | 24 (4.5) | 35 (6.0) | 38 (6.4) | — |
| 4+ | 6 (1.1) | 2 (0.4) | 16 (3.0) | 46 (7.8) | 57 (9.6) | — |
| HPV 6, 11, 16, 18 | ||||||
| 0 | 484 (88.8) | 480 (90.7) | 427 (80.7) | 439 (74.8) | 411 (69.5) | 457 (77.2) |
| 1 | 52 (9.5) | 46 (8.7) | 83 (15.7) | 101 (17.2) | 124 (21.0) | 93 (15.7) |
| 2 | 8 (1.5) | 3 (0.6) | 15 (2.8) | 39 (6.6) | 45 (7.6) | 31 (5.2) |
| 3 | 1 (0.2) | 0 (0.0) | 4 (0.8) | 7 (1.2) | 10 (1.1) | 9 (1.5) |
| 4 | 0 (0.0) | 0 (0.0) | 0 (0.0) | 1 (0.2) | 1 (0.2) | 2 (0.3) |
*
HPV 6, 11, 16, 18, 31, 33, 35, 39, 45, 51, 52, 56, 58, and 59.