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. Author manuscript; available in PMC: 2012 Apr 1.
Published in final edited form as: Gene Ther. 2010 Nov 11;18(4):344–353. doi: 10.1038/gt.2010.139

Figure 5.

Figure 5

MKP-1 gene transfer alleviated bone resorption in rats after LPS challenge. Eight-week-old of male Sprague-Dawley rats (17 rats/group) were injected either Ad.MKP-1, or Ad. LacZ (1×109 pfu in 4 μl), or HEPES buffered saline (4 μl). Forty-eight hours after the adenovirus injection, the rats were injected with 2μl of either 20 μg of LPS (from A. actinomycetemcomitans) or PBS three times a week for four weeks. (a) Representative microcomputed tomography images of rat maxillae from indicated treatment groups. (b) Volumic analysis of bone loss levels (n=7 for PBS groups, n=10 for LPS groups, *p<0.05).

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