Table 7.
Second Generation Antimicrobials
| Antimicrobial | Cetylpyridinium chloride | Chlorhexidine |
|---|---|---|
| Commercial Name | Crest Pro-Health (Procter & Gamble) | Peridex (3M Espe) Periogard (Colgate) |
| ADA Seal of Acceptance | No | Yes |
| Active ingredients | 0.07% CPC | 0.12% Chlorhexidine gluconate (http://solutions.3m.com/wps/portal/3M/en_US/preventive-care/home/products/home-care-therapies/peridex/) and (http://www.colgateprofessional.com/products/Colgate-Periogard-Rinse-Rx-only/details) |
| Mechanism of Action | Bactericidal agent interacts with the bacterial membrane. The cellular pressure disrupts the cell membrane and effectively kills the bacteria. | Positively charged chlorhexidine molecule binds to negatively charged microbial cell wall, altering osmotic equlibrium, causing potassium and phosphorous leakage, precipitation of cytoplasmic contents and consequent cell death. |
| Efficacy published by the manufacturer | Similar to Listerine (http://www.dentalcare.com/soap/products/index.htm) | Certain aerobic and anaerobic bacteria reduction from 54 – 97% through six months use (http://solutions.3m.com/wps/portal/3M/en_US/preventive-care/home/products/home-care-therapies/peridex/)
|