Table 1.
S. purpuratus homologs of conserved Polycomb group proteins
| Predicted PcG Complex* |
Gene Name | Genbank accession |
Predicted polypeptide length |
Domains and function | Homologs (BLAST score) |
|---|---|---|---|---|---|
| PhoRC | Sp-Pho | XP_790188 | 400 | C2H2 Zn-finger (4) transcription factor, binds Polycomb Responsive Elements (PREs) |
D. rerio (8e-112) H. sapiens (2e-104) |
| Sp-Mbt1 | XP_785195 | 1805 | MBT-domain (3), Sterile α-motif (SAM) protein-protein interaction domain |
M. musculus (9e-83) H. sapiens (4e-82) |
|
| Sp-Mbt2 |
XP_001202275 XP_001201293 |
1944 | MBT-domain (4), SAM protein-protein interaction domain |
G. gallus (2e-142) H. sapiens (4e-141) |
|
| Sp-L(3)mbt | XP_792284 | 992 | MBT-domain (3), C2H2 Zn-finger (2), SAM protein-protein interaction domain |
H. sapiens (1e-180) M.musculus (3e-179) |
|
|
| |||||
| PRC2 | Sp-Ezh2 | XP_790741 | 551 | SET-domain histone methyltransferase, specific tri-methylation of H3K27 recognized by the Polycomb (Pc) chromodomain |
X. tropicalis (2e-179) H. sapiens (5e-179) |
| Sp-Eed | XP_786345 | 461 | WD40-domains (5) coordinate multi-protein complex assemblies as a scaffold for protein interactions |
D. rerio (2e-157) H. sapiens (2e-156) |
|
| Sp-Suz12 | XP_788076 | 757 | No defined domains, required for HTMase and silencing activity of the EED-EZH2 complex |
D.rerio (4e-123) M. musculus (1e-122) |
|
| Sp-Rbbp4 | XP_780271 | 430 | WD40-domains (5) |
M. musculus (0.0) H. sapiens (0.0) |
|
|
| |||||
| PRC1 | Sp-Pc1 | SPU_20586 | 1393 | Chromodomain, chromatin organization modifier domain involved in promoting heterochromatin condensation |
R. norvegicus (1e-22) C. familiaris (2e-22) |
| Sp-Pc2 | SPU_20946 | 456 | Chromodomain |
D. melanogaster (7e-16) R. norvegicus (2e-16) |
|
| Sp-Ph | XP_789940 | 788 | Zn-finger, SAM protein-protein interaction domain |
H. sapiens (5e-50) M. musculus (9e-50) |
|
| Sp-Psc | XP_783799 | 479 | C3CH4 Zn-finger (RING-finger) domain |
M. musculus (3e-54) H. sapiens (9e-54) |
|
| Sp-Ring1 | XP_788976 | 306 | C3CH4 Zn-finger (RING-finger) domain |
M. musculus (3e-93) H. sapiens (4e-93) |
|
*
The S. purpuratus polycomb group protein homologs are categorized based on genetic and biochemical evidence of complex association from their respective counterparts in various animals