. Author manuscript; available in PMC: 2011 May 3.

Published in final edited form as: Dev Dyn. 2009 Jan;238(1):110–122. doi: 10.1002/dvdy.21829

Table 2.

Data shows the various phenotypes of heterozygous and null embryos separated into four categories. Using pifithrin-α treatment on pregnant females we were able to find a partial rescue for heterozygous mice but none for homozygous nulls.

Categories:	Heterozygotes:		Homozygous Nulls:
	PFT treated	DMSO treated	PFT treated	DMSO treated
1. Normal	27(79%)	18(46%)	0(0%)	0(0%)
2. Postneurulation, partial open NT	6(18%)	15(38%)	0(0%)	0(0%)
3. Hypomorphism, heart defects, open NT, failure to turn	1(3%)	5(13%)	1(14%)	0(0%)
4. No development beyond E8.5 stage	0(0%)	1(3%)	6(86%)	7(100%)