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Synthesis of (+)-sclerotioin 2.
a) 2.2 equiv. Cu(CH3CN)4PF6, 2.4 equiv. N-ethyl-(+)-sparteine mimic 6, 1.6 equiv. DIEA, 2.4 equiv. DMAP, O2, −78°C to −10°C; b) aq. H2PO4/K2HPO4 buffer (pH 7.2), CH3CN, rt 76% over two steps c) acetic anhydride, DMAP, DIEA, 0°C, 30 min d) NCS, CH3CN, rt, 24 h 65% over two steps; e.) NH4OAc, MeOH, 30 min, 60%.
