Figure 4.

Analysis of overlapping expression profiles and novel epistatic relationships between genes that are necessary for SC proliferation. siRNA and inhibitor treatments were expression profiled to identify downstream effectors of SC proliferation. A, Numbers indicate genes differentially expressed in three treatments that each individually inhibit SC proliferation. Three genes are commonly downregulated, one of which is CEBPG. B, Novel epistatic relationships can be inferred from TF expression profiling siRNA and inhibitor treatments. CEBPG can be placed downstream of JNK and JUND and the other commonly downregulated genes, BTAF1 and LRP5.