Table 2.
Genes commonly differentially expressed in treatments that inhibit sensory epithelia proliferation
| Gene | Downstream of Ap-1 pathway |
Pax pathway |
||||||
|---|---|---|---|---|---|---|---|---|
| CEBPG siRNA | p value | LRP5 siRNA | p value | PAX2 siRNA | p value | PAX5 siRNA | p value | |
| MYT1L | −4.27 | 7 × 10−3 | −4.05 | 7.00 × 10−3 | −1.51 | 2.00 × 10−3 | −1.61 | 1.40 × 10−2 |
| WNT4 | 5.41 | 1.70 × 10−2 | 4.16 | 3.90 × 10−2 | 1.34 | 4.70 × 10−2 | 1.37 | 7.00 × 10−3 |
Expression profiles for siRNA knockdowns that inhibited sensory epithelia proliferation were compared to identify specific commonalities downstream of the Ap-1 and PAX pathways. MYT1L and WNT4 were commonly differentially expressed (average fold change >1.3, p < 0.05) in all four siRNA treatments that inhibit proliferation.